When the news hit the dominant medical industry in January 1993 that 33% of adult Americans used some “unconventional medicine” and spent $13.7-billion annually out of their pockets, most of the medical industry’s stakeholders were startled awake. A huge cultural-medical phenomenon had been obscured by their prejudice. The awakening was all the more effective because the data that grabbed them was from the inner sanctum. The research hailed from Harvard University. The results were published in the top-cited New England Journal of Medicine (NEJM). The Harvard brand was then affixed to high profile conferences that sanctified and kick-started the integrative era. While the first leaders have moved in powerful new directions, 27 years later, the Osher Center for Integrative Medicine at Harvard Medical School and Brigham and Women’s Hospital is being led by director Peter Wayne, PhD and a new generation that substantially grew up inside the institution. Returning to Harvard seemed a good way to cap the series of 6 portraits of integrative academic health centers – from the shock waves via peer-reviewed journal to anticipated next-gen directions.