In May of 2018 at the top global research meeting for integrative health and medicine, two academic leaders with medical cannabis practices organized an informal breakfast round-table. One co-convenor helping guide dialogue in the overflow room was Leslie Mendoza Temple, MD. The past chair of the politically-killed Illinois Medical Cannabis Advisory Board brought more than personal reflection to the attendees. Temple had performed a comprehensive chart review on the first 166 medical cannabis patients certified in the practice. Her findings, recently published, and her reflections on now 650 patients – plus the curious politics of cannabis in her state – will be eye-opening for practitioners tracking medical cannabis developments.