The way Joe Selby, MD, MPH tells it, the naming of the $3.2-billion Patient Centered Outcomes Research Institute (PCORI) – which from the outset had a charge to explore the comparative effectiveness of complementary and alternative medicine methods – was both serendipitous and brilliant. At the time the quasi-public agency was established as part of the Affordable Care Act, the idea of “comparative effectiveness research (CER)” a hot-potato for the medical industry. Medicine’s waste, morbidity, mortality and cost prompted interest in real-world, decision-oriented research. But powerful medical stakeholders were worried enough about the comparative effectiveness of their part of the status quo that elevating a “CER Institute” was not attractive. The patient centered name was a political compromise. It captured something of the real world. And what politician or stakeholder could oppose a name like that? In this interview at the end of his 9 year stint as PCORI’s founding executive director, Selby shares some of the “undeniable influence” – including at the NIH and the FDA and in discovering influences on cost savings that is growing out of PCORI’s active placement of patients at the table in decision-making.